C4 induces pathological synaptic loss by impairing AMPAR trafficking.
Rhushikesh A. Phadke, Ezra Kruzich, Luke A. Fournier, Alison Brack, Mingqi Sha, Ines Picard, Connor Johnson, Dimitri Stroumbakis, Maria Salgado, Charlotte Yeung, Berta Escude Velasco, Yen Yu Liu, Alberto Cruz‐Martín
This study shows that C4 overexpression causes synaptic loss by impairing GluR1 trafficking via SNX27, independent of the complement pathway.
bioRxiv · Sep 9, 2023 · PreprintNeuroscience