ER Stress-Response Signaling Regulates Chamber-Specific Growth between Right and Left Ventricles during Postnatal Development.
Boyang Zhang, Michał Juda, Jijun Huang, Douglas J. Chapski, Adrian Arrieta, Isaac Rodney, Jinge Liu, Michael Leone, Tzung K. Hsiai, Yibin Wang, Tomohiro Yokota
This study identifies the IRE1-Xbp1-Vimp/Rpn2 axis as a regulator of differential growth between left and right ventricles during postnatal development by modulating cardiomyocyte proliferation, hypertrophy, and apoptosis.
bioRxiv · Jul 21, 2026 · PreprintDevelopmental Biology