Complement receptor-mediated uptake into renal mononuclear phagocytes promotes intracellular UPEC persistence and limits β-lactam efficacy in pyelonephritis
Beata Goldyn, Olena Babyak, Pranitha Rokkam, Yevheniia Minchuk, Marigona Sutaj, Clivia Lisowski, Nicolette Bluszcz, Daniela Klaus, Annika Voelkel, Amina Abdelmageed, Junping Yin, Andrew J. Kueh, Huiyun Hu, Isabelle Mueller, Marco J. Herold, , Christian Kurts
This study identifies renal mononuclear phagocytes as an intracellular reservoir for UPEC in pyelonephritis, showing that complement receptor-mediated entry promotes bacterial persistence and limits β-lactam efficacy.
bioRxiv · Jul 9, 2026 · PreprintMicrobiology