High-Dimensional Spatiotemporal Single-Cell and 3D Atlas of the Bone Marrow Microenvironment during Leukemic Progression
Lan‐Zhu Li, Isabelle Rottmann, Geoffrey T. Ivison, Huan Jun Wei, Jan C. Schroeder, Gina Dunkel, Yury Goltsev, Garry P. Nolan, Aaron T. Mayer, Borhan R. Saeed, Bettina Weigelin, Christian M. Schürch
This study maps the spatiotemporal changes in the bone marrow microenvironment during CML progression using single-cell and 3D imaging, revealing immune evasion and niche disruption.
bioRxiv · Sep 27, 2025 · PreprintCancer Biology