J. A. Sorg

The small acid-soluble proteins of Clostridioides difficile regulate sporulation in a SpoIVB2-dependent manner

This paper identifies SpoIVB2 as a regulator of sporulation in C. difficile, showing that SASPs are required for spore cortex formation and interact with SpoIVB2.

Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation

This paper identifies bile salt hydrolase activity in C. difficile that specifically targets taurine-derived bile salts and influences biofilm formation through interactions with C. scindens.

Imaging Clostridioides difficile spore germination and germination proteins

This study visualizes C. difficile spore germination proteins using TEM and SEM, showing their localization to the spore cortex.

Clostridioides difficile SpoVAD and SpoVAE interact and are required for DPA packaging into spores

This study identifies SpoVAD and SpoVAE as essential for DPA packaging into C. difficile spores and shows they interact with SpoVAC at the inner spore membrane.

The small acid-soluble proteins of Clostridioides difficile are important for UV resistance and serve as a check point for sporulation.

This paper investigates the role of small acid-soluble proteins (SASPs) in UV resistance and spore formation in C. difficile, finding that SspA is essential for UV resistance and SspA/SspB regulate spore formation.

The selenophosphate synthetase, selD, is important for Clostridioides difficile physiology

This study shows that the selD gene, which encodes selenophosphate synthetase, is crucial for Clostridioides difficile physiology, affecting growth, sporulation, and post-germination outgrowth.

The requirement for the amino acid co-germinant during C. difficile spore germination is influenced by mutations in yabG and cspA

This study identifies mutations in yabG and cspA that alter the requirement for amino acid co-germinants during C. difficile spore germination, revealing their role in germinant receptor function.