Development of LIBRA-seq for the Guinea Pig Model System as a Tool for the Evaluation of Antibody Responses to Multivalent HIV-1 Vaccines
M. J. Vukovich, N. Raju, P. Kgagudi, N. P. Manamela, A. A. Abu-Shmais, K. R. Gripenstraw, P. T. Wasdin, S. Shen, B. Dwyer, J. Akoad, R. M. Lynch, D. C. Montefiori, S. I. Richardson, P. L. Moore, I. S. Georgiev
This paper evaluates multivalent HIV-1 Env immunization strategies in guinea pigs and adapts LIBRA-seq for antibody discovery, finding optimal cocktail sizes and identifying public clonotypes.
bioRxiv · Sep 25, 2023Immunology