S. Shen

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

Proteomics analysis reveals novel phosphorylated residues and associated proteins of the polyomavirus DNA replication initiation complex.

Structural insights into specific recognition of PTENα/β-NTE by WDR5 in cancer progression

The paper determines the crystal structure of PTEN-NTE bound to WDR5, revealing a specific binding motif that promotes tumor growth and suggests WDR5 inhibitors as potential cancer therapies.

Beyond BioID: Streptavidin outcompetes antibody fluorescence signals in protein localization and readily visualises targets evading immunofluorescence detection.

This paper demonstrates that streptavidin-based imaging outperforms immunofluorescence in detecting low-abundance or inaccessible proteins and reveals dynamic protein interactions.

Fecal microbial transfer and complex carbohydrates mediate protection against COPD

This study shows that fecal microbial transfer and complex carbohydrates can reduce COPD symptoms in mice and humans, linking gut microbiota to disease progression.

DNA damaged-induced phosphorylation of a viral replicative DNA helicase results in inhibition of DNA replication through attenuation of helicase function

This study shows DDR phosphorylation of SV40 LT at T518 inhibits DNA replication by reducing helicase activity without affecting ATPase function or protein interactions.

Development of LIBRA-seq for the Guinea Pig Model System as a Tool for the Evaluation of Antibody Responses to Multivalent HIV-1 Vaccines

This paper evaluates multivalent HIV-1 Env immunization strategies in guinea pigs and adapts LIBRA-seq for antibody discovery, finding optimal cocktail sizes and identifying public clonotypes.

Activation-induced shift in nutrient preference and function-specific nutrient dependence in human neutrophils

This study shows that human neutrophils shift nutrient preference from glycogen to glucose upon activation, with function-specific metabolic dependencies.

Exogenous Methylglyoxal Improves Maize Yield by Alleviating Plant Diabetes and leaf senescence under Drought

This study shows exogenous methylglyoxal alleviates drought-induced leaf senescence and yield loss in maize by improving sugar metabolism and activating defense pathways.

High red/far-red ratio promotes root colonization of Serratia plymuthica A21-4 in tomato by root exudates-stimulated chemotaxis and biofilm formation

In Vivo Three-dimensional Brain Imaging with Chemiluminescence Probes in Alzheimers Disease Models

This paper develops chemiluminescence probes for in vivo 3D brain imaging in Alzheimer's disease models, showing high photon emission and binding to amyloid beta.

Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies to self-antigens

The paper identifies auto-antibodies secreted by plasma cells in PDAC against self-antigens, suggesting a link between chronic inflammation and autoimmunity.

Metabolic interplay between Proteus mirabilis and Enterococcus faecalis facilitates polymicrobial biofilm formation and invasive disease

This study identifies a metabolic interaction between Proteus mirabilis and Enterococcus faecalis that enhances biofilm formation and CAUTI severity.

Proliferating cell nuclear antigen involves in temperature stress tolerance of Ulva prolifera

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

Translational control by Trypanosoma brucei DRBD18 contributes to the maintenance of the procyclic state

This study shows that DRBD18 in Trypanosoma brucei regulates translational efficiency of specific transcripts, maintaining the procyclic form by repressing procyclic-specific proteins and enhancing bloodstream/metacyclic-specific proteins.

Identification of key virus--prokaryote infection pairs that contribute to viral shunt in a freshwater lake

The paper identifies key virus-prokaryote infection pairs that drive viral shunt in a freshwater lake by analyzing metagenomic data from surface and deep layers over a year.

A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish

This paper identifies a novel lymphoid network in zebrafish that enables whole-body T cell surveillance without lymph nodes, supporting both collective migration and antigen search.

CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment

This paper develops and tests a CD46-targeted alpha radioimmunotherapy, 212Pb-TCMC-YS5, showing potent tumor growth inhibition and survival improvement in multiple prostate cancer models.

Highly synchronized cortical circuit dynamics mediate spontaneous pain

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

Distinct Single-cell Immune Ecosystems Distinguish True and De Novo HBV-related Hepatocellular Carcinoma Recurrences

This study identifies distinct immune ecosystems in true and de novo HBV-related HCC recurrences using single-cell and bulk RNA-sequencing, revealing differences in T cell phenotypes and immune interactions that may inform immunotherapy strategies.

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

The interactome of Cryptococcus neoformans Rmt5 reveals multiple regulatory points in fungal cell biology and pathogenesis

This study identifies Rmt5 as a critical regulator of Cryptococcus neoformans morphology and virulence by characterizing its interactome and phenotypic effects.

5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing

This study reveals the structural basis of SETD2 methyltransferase interaction with hnRNP L paralogs, showing how a leucine pair in SETD2 interacts with hnRNP L RRM2 and affects splicing regulation.

Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression ofPAK3 via miRNA regulation

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

Occurrence of COVID-19 symptoms during SARS-CoV-2 infection defines waning of humoral immunity

The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.

Proteasome maturation factor UMP1 confers broad-spectrum disease resistance by modulating H2O2 accumulation in rice

A natural allele of rice UMP1 promotes resistance to multiple pathogens by boosting H2O2 accumulation.

Insights into the susceptibility of rice to a floral disease

The fungal pathogen Ustilaginoidea virens disarms chitin-triggered immunity in rice flower via a secreted chitinase, revealing a mechanism of disease susceptibility.

Single-cell transcriptomics reveal cell type-specific molecular changes and altered intercellular communications in chronic obstructive pulmonary disease

This study uses single-cell RNA sequencing to identify cell type-specific molecular changes and altered intercellular communications in COPD, linking them to alveolar epithelial dysfunction.