The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2
T. J. Berg, C. Marques, V. Pantazopoulou, E. Johansson, K. von Stedingk, D. Lindgren, E. J. Pietras, T. Bergström, F. J. Swartling, V. Governa, J. Bengzon, M. Belting, H. Axelson, M. Squatrito, A. Pietras
This study shows that irradiated astrocytes promote glioma stemness and survival through TGM2, suggesting targeting this pathway could improve radiotherapy outcomes.
bioRxiv · Feb 12, 2020Cancer Biology