Structure-activity relationship of flavin analogs that target the FMN riboswitch
Q. Vicens, E. Mondragon, F. E. Reyes, P. Coish, P. Aristoff, J. Bermann, H. Kaur, K. W. Wells, P. Wickens, J. Wilson, R. C. Gadwood, H. J. Schostarez, R. K. Suto, K. F. Blount, R. T. Batey
The paper describes the structure-based design of flavin analogs targeting the FMN riboswitch, identifying 5FDQD as an effective antibacterial compound.
bioRxiv · Aug 9, 2018Biochemistry