J. Wilson

Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19

The paper identifies distinct type 1 immune networks associated with varying severities of restrictive lung disease following COVID-19.

Exploring the impact of variability in cell segmentation and tracking approaches

The paper quantifies variability in manual and automated cell segmentation and tracking methods, showing their impact on phenotypic metrics and reproducibility.

An Injectable Subcutaneous Colon-Specific Immune Niche For The Treatment Of Ulcerative Colitis

This paper develops a subcutaneous colon-specific immune niche to treat ulcerative colitis, showing it reduces inflammation and prevents cancer in mouse models.

Characterization of cotton virus A, a novel and distinct member of the genus Caulimovirus with endogenous viral elements in Gossypium spp.

The paper characterizes cotton virus A, a new Caulimovirus, and identifies endogenous viral elements in some cotton species.

Origin of biogeographically distinct ecotypes during laboratory evolution

This study shows how mutations in microbial species lead to resource partitioning and improved community productivity in a simulated subsurface environment.

An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics

This paper describes a cell-free biomanufacturing approach for rapid production of griffithsin, a broad-spectrum antiviral protein, demonstrating its efficacy against SARS-CoV-2 and HIV-1.

DNA double helix, a tiny electromotor

The paper demonstrates that a DNA or RNA duplex rotates unidirectionally at high speed under an electric field, driven by electro-osmotic flow, and shows potential for nanoscale engineering applications.

Growth phase estimation for abundant bacterial populations sampled longitudinally from human stool metagenomes.

This paper estimates growth phases of gut bacterial populations in human stool metagenomes using a steady-state flow-through model, finding slower defecation correlates with more taxa in later growth phases.

Large haploblocks underlie rapid adaptation in an invasive weed

This study identifies large haploblocks as key drivers of rapid local adaptation in Ambrosia artemisiifolia across different climates.

ALT Neuroblastoma Chemoresistance due to ATM Activation by Telomere Dysfunction is Reversible with the ATM Inhibitor AZD0156

This study shows that ATM activation due to telomere dysfunction causes chemoresistance in ALT neuroblastoma, which can be reversed by the ATM inhibitor AZD0156.

Adaptive introgression and standing genetic variation, two facilitators of adaptation to high latitudes in European aspen (Populus tremula L.)

This study identifies adaptive introgression and standing genetic variation as key factors in European aspen's adaptation to high latitudes through genomic analysis of 411 trees.

Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology

This study identifies spatially confined sub-tumor microenvironments in PDAC that drive distinct tumor progression outcomes.

The innate immunity protein C1QBP functions as a negative regulator of circulative transmission of Potato leafroll virus by aphids

This study identifies C1QBP as a negative regulator of Potato leafroll virus transmission by aphids using AP-MS and functional assays.

The Effect of Radiotherapy on Head and Neck Cancer Cell Lines Following Exposure to Heat

This study investigates whether heat treatment enhances radiotherapy sensitivity in head and neck cancer cells by affecting the ATR pathway.

Nfkbid is required for immunity and antibody responses to Toxoplasma gondii

This study identifies Nfkbid as essential for immunity and antibody responses to Toxoplasma gondii, showing its role in B cell activation, B-1 cell development, and vaccine efficacy.

Synergistic epistasis enhances cooperativity of mutualistic interspecies interactions

The paper investigates how synergistic epistasis enhances cooperativity in mutualistic interspecies interactions between Desulfovibrio vulgaris and Methanococcus maripaludis under varying sulfate conditions.

A Novel Method of Immunomodulation of Endothelial cells Using Streptococcus Pyogenes and its Lysate

This study investigates a novel method of immunomodulating endothelial cells using Streptococcus pyogenes and its lysate, showing changes in biomarkers and cytokine production.

An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias

The paper develops a QSP model to predict drug-induced myelosuppression across multiple hematopoietic lineages and validates it with known drug mechanisms.

Investigations into the declining health of alder (Alnus glutinosa) along the river Lagan in Belfast, including the first report of Phytophthora lacustris causing disease of Alnus in Northern Ireland

The paper surveys alder trees along the river Lagan in Belfast, identifying Phytophthora lacustris as a new pathogen causing disease in Alnus glutinosa in Northern Ireland.

Organic soil amendment with Spent Mushroom Substrate results in fungal colonisation, alters bacterial-fungal co-occurrence patterns and improves plant productivity.

This study examines how spent mushroom substrate affects soil microbial communities and plant productivity over 14 weeks.

Differential expression of soluble receptor for advanced glycation end-products (sRAGE) in mice susceptible or resistant to chronic colitis

The paper identifies sRAGE as a protective factor against chronic colitis in mice and humans by comparing resistant and susceptible models and validating findings in clinical samples.

A Metagenomic Comparison of Tracheal Aspirate and Mini-Bronchial Alveolar Lavage for Assessment of Respiratory Microbiota

This paper compares metagenomic sequencing of tracheal aspirates and mini-bronchial alveolar lavage to assess respiratory microbiota and develop diagnostic models for lower respiratory tract infections.

Structure-activity relationship of flavin analogs that target the FMN riboswitch

The paper describes the structure-based design of flavin analogs targeting the FMN riboswitch, identifying 5FDQD as an effective antibacterial compound.