MicrobiologybioRxivPreprint
TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2
A. Aggarwal, C. Fichter, V. Milogiannakis…·S. G. Turville
The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.
DOI 10.1101/2023.09.22.558930