Author

A. Khromykh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

R. Parry· 3 shared L. Burr· 2 shared A. A. Amarilla· 1 shared A. Aggarwal· 1 shared A. Akerman· 1 shared A. D. Kelleher· 1 shared A. Kindinger· 1 shared A. Slonchak· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

R. Parry

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2

A. Aggarwal, C. Fichter, V. Milogiannakis, T. Ison, M. Ruiz Silva, C. Esneau, N. Bartlett, L. Burrell, S. Patel, M. Churchill, T. Angelovich, R. Parry, J. D. Sng, G. G. Neely, C. L. Moreno, , S. G. Turville

The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.

bioRxiv · Sep 22, 2023 · PreprintMicrobiology

A novel tamanavirus (Flaviviridae) of the European common frog (Rana temporaria) encodes a divergent class 1b XRN1-resistant RNA element.

R. H. Parry, A. Slonchak, L. J. Campbell, N. Newton, H. Debat, R. J. Gifford, A. Khromykh

This paper identifies a novel tamanavirus in European common frogs, RaTV, which encodes a divergent XRN1-resistant RNA element similar to flaviviruses.

bioRxiv · Jul 6, 2023Microbiology

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 Gamma variant

C. L. Pegg, N. Modhiran, R. Parry, B. Liang, A. A. Amarilla, A. Khromykh, L. Burr, P. Young, K. Chappell, B. L. Schulz, D. Watterson

This study compares glycosylation and antigenicity of SARS-CoV-2 Wu-1 and Gamma variants, finding that an NTD mutation alters glycan site occupancy but not antibody binding.

bioRxiv · Apr 3, 2023 · PreprintBiochemistry

Oxysterols drive inflammation via GPR183 during influenza virus and SARS-CoV-2 infection

C. X. Foo, S. Bartlett, K. Y. Chew, M. D. Ngo, H. Bielefeldt-Ohmann, B. J. Arachchige, B. Matthews, S. Reed, R. Wang, M. J. Sweet, L. Burr, J. E. Sinclair, R. Parry, A. Khromykh, K. R. Short, , K. Ronacher

This study identifies oxysterols and GPR183 as drivers of inflammation in the lung during influenza and SARS-CoV-2 infections, showing that targeting GPR183 reduces inflammation and disease severity.

bioRxiv · Jun 14, 2022Immunology