GDF15 mediates inflammation-associated bone loss through a brain-bone axis
R. Van der Cruyssen, J. Devan, I. Heggli, D. Burri, D. Gaublomme, I. Josipovic, E. Dumas, C. Vlieghe, M. G. Raimondo, P. Zakharov, P. Jacques, S. De Mits, Z. Lukasik, M. Vuylsteke, T. Renson, , D. Elewaut
This study identifies GDF15 as a mediator of inflammation-associated bone loss via a brain-bone axis, showing it induces bone loss through GFRAL receptor activation in the hindbrain.
bioRxiv · Nov 22, 2023 · PreprintImmunology