J. Dommann

A novel barcoded nanopore sequencing workflow of high-quality, full-length bacterial 16S amplicons for taxonomic annotation of bacterial isolates and complex microbial communities

This paper introduces a nanopore sequencing workflow for high-quality, full-length 16S rDNA amplicons to identify bacterial isolates and profile microbial communities, showing high agreement with MALDI-TOF and strong correlation with Illumina sequencing.

Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation.

This study shows that ivermectin and moxidectin inhibit gut bacterial growth and induce antibiotic-like resistance, raising concerns about cross-resistance to other antibiotics.