Multiple evolutionary pathways lead to vancomycin resistance in Clostridioides difficile
J. E. Buddle, R. C. T. Wright, C. E. Turner, R. R. Chaudhuri, M. A. Brockhurst, R. P. Fagan
This study shows that C. difficile can evolve vancomycin resistance through two pathways, but resistance comes with fitness costs and sporulation defects that may limit its clinical impact.
bioRxiv · Sep 15, 2023 · PreprintMicrobiology