Author

C. E. Turner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:host-pathogen & immune response· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2

Frequent Co-Authors

S. Sriskandan· 4 shared H. Khalid· 2 shared R. R. Chaudhuri· 2 shared A. I. Bordin· 1 shared A. J. Keeley· 1 shared A. K. Sesay· 1 shared A. Remmington· 1 shared A. Schricker· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersMicrobiology

S. Sriskandan

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point Mutation

L. Kobrossy, W. Xu, C. Zhang, W. Feng, C. E. Turner, M. S. Cosgrove

This study introduces a point mutation in MLL1 in iPS cells to mimic MLL1F-LSCs phenotypes, revealing that loss of MLL1 enzymatic activity drives H3K4 trimethylation via mislocalized SETd1a.

Journal of Biological Chemistry · Nov 1, 2024Peer-reviewedCancer Biology

Multiple evolutionary pathways lead to vancomycin resistance in Clostridioides difficile

J. E. Buddle, R. C. T. Wright, C. E. Turner, R. R. Chaudhuri, M. A. Brockhurst, R. P. Fagan

This study shows that C. difficile can evolve vancomycin resistance through two pathways, but resistance comes with fitness costs and sporulation defects that may limit its clinical impact.

bioRxiv · Sep 15, 2023 · PreprintMicrobiology

CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway

L. R. Green, R. Issa, F. Albaldi, L. Urwin, H. Khalid, C. E. Turner, B. Ciani, L. J. Partridge, P. N. Monk

This study shows CD9 and syndecan-1 cooperate for staphylococcal adhesion, with fibronectin also playing a role, and suggests CD9-targeted therapies could block bacterial entry.

bioRxiv · Jan 17, 2023Microbiology

Characterisation of emergent toxigenic M1UK Streptococcus pyogenes and associated sublineages

H. K. Li, X. Zhi, A. Vieira, H. J. Whitwell, A. Schricker, E. Jauneikaite, H. Li, A. Yosef, I. Andrew, L. Game, C. E. Turner, T. Lamagni, J. Coelho, S. Sriskandan

This study characterizes the M1UK sublineage of Streptococcus pyogenes, identifying genetic and phenotypic differences that contribute to its dominance and increased virulence.

bioRxiv · Dec 27, 2022Microbiology

Comparative genomic analysis of skin and soft tissue Streptococcus pyogenes isolates from low- and high-income settings

S. Y. Bah, A. J. Keeley, E. P. Armitage, H. Khalid, R. R. Chaudhuri, E. Senghore, J. Manneh, L. Tilley, M. Marks, S. Darboe, A. K. Sesay, T. I. de Silva, C. E. Turner, The MRCG StrepA Study Group

This study compares the genomes of Streptococcus pyogenes isolates from low- and high-income settings, revealing genetic diversity and differences in resistance genes and prophage content.

bioRxiv · Sep 10, 2021 · PreprintMicrobiology

Antibody Activities in Hyperimmune Plasma Against the Rhodococcus equi Virulence -Associated Protein A or Poly-N-Acetyl Glucosamine are Associated with Protection of Foals Against Rhodococcal Pneumonia

S. K. Kahn, C. Cywes-Bentley, G. P. Blodgett, N. M. Canaday, C. E. Turner, M. Vinacur, S. C. Cortez-Ramirez, P. J. Sutter, S. C. Meyer, A. I. Bordin, D. R. Vlock, G. B. Pier, N. D. Cohen

This study assesses the protective efficacy of hyperimmune plasma against Rhodococcus equi pneumonia in foals by analyzing antibody activities against specific antigens.

bioRxiv · Apr 6, 2021Immunology

Vaccine-induced, but not natural immunity, against the Streptococcal Inhibitor of Complement protects against invasive disease

L. K. K. Tan, M. Reglinski, D. Teo, N. Reza, L. E. M. Lamb, V. Nageshwaran, C. E. Turner, M. Wikstroem, I.-M. Frick, L. Bjorck, S. Sriskandan

This study shows that vaccine-induced antibodies against SIC provide protection against invasive S. pyogenes infection, while natural antibodies do not.

bioRxiv · Nov 22, 2020Microbiology

Cryptic prophages within a Streptococcus pyogenes genotype emm4 lineage

A. Remmington, S. Haywood, J. Edgar, C. E. Turner

This study identifies a cryptic prophage lineage in emm4 Streptococcus pyogenes isolates, showing gene loss and reduced inducibility compared to other strains.

bioRxiv · May 19, 2020Microbiology

The emergence of successful Streptococcus pyogenes lineages through convergent pathways of capsule loss and recombination directing high toxin expression

C. E. Turner, M. T. Holden, B. Blane, C. Horner, S. J. Peacock, S. Sriskandan

The paper identifies convergent evolutionary pathways in Streptococcus pyogenes lineages through recombination at the nga-slo locus and capsule loss, associated with increased toxin expression and disease success.

mBio · Dec 24, 2019Peer-reviewedMicrobiology

Streptococcal superantigen-induced expansion of human tonsil T cells leads to altered T follicular helper cell phenotype, B cell death, and reduced immunoglobulin release

F. J. Davies, C. Olme, N. N. Lynskey, C. E. Turner, S. Sriskandan

This study shows that streptococcal superantigens alter T follicular helper cell phenotype, induce B cell death, and reduce immunoglobulin release in human tonsil cells.

bioRxiv · Aug 19, 2018Microbiology