The Host Cell's Endoplasmic Reticulum Proteostasis Network Profoundly Shapes the Protein Sequence Space Accessible to HIV Envelope
J. Yoon, E. E. Nekongo, J. E. Patrick, A. M. Phillips, A. I. Ponomarenko, S. J. Hendel, V. L. Butty, C. B. Ogbunugafor, Y.-S. Lin, M. D. Shoulders
This study shows that upregulating the host ER proteostasis network via the UPR reduces mutational tolerance of HIV Env, with some regions becoming more tolerant, suggesting host proteostasis influences HIV adaptation.
bioRxiv · Apr 24, 2021Biochemistry