The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics
D. J. Sherman, L. Liu, J. L. Mamrosh, J. Xie, J. Ferbas, B. Lomenick, M. S. Ladinsky, R. Verma, I. C. Rulifson, R. J. Deshaies
This study investigates the cellular effects of the PNPLA3-I148M variant, revealing its role in altering lipid droplet-Golgi dynamics and inducing proteomic and transcriptomic changes associated with liver disease.
bioRxiv · Oct 13, 2023Cell Biology