Cell BiologybioRxiv
The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics
D. J. Sherman, L. Liu, J. L. Mamrosh…·R. J. Deshaies
This study investigates the cellular effects of the PNPLA3-I148M variant, revealing its role in altering lipid droplet-Golgi dynamics and inducing proteomic and transcriptomic changes associated with liver disease.
DOI 10.1073/pnas.2318619121