Triggering closure of a sialic acid TRAP transporter substrate binding protein through binding of natural or artificial substrates
M. F. Peter, C. Gebhardt, J. Glaenzer, N. Schneberger, M. de Boer, G. H. Thomas, T. Cordes, G. Hagelueken
This study investigates the conformational changes in the sialic acid TRAP transporter SBP VcSiaP upon substrate binding, showing that substrate induces closure and provides structural insights for inhibitor development.
bioRxiv · Dec 2, 2020Biophysics