Increased frequency of CD4+ and CD8+ follicular helper T cells in human lymph node biopsies during the earliest stages of rheumatoid arthritis
D. C. Anang, T. H. Ramwadhdoebe, J. Hahnlein, B. van Kuijk, N. Smits, K. P. van Lienden, M. Maas, D. M. Gerlag, P. P. Tak, N. de Vries, L. G. van Baarsen
The paper examines Tfh cell frequencies and cytokine profiles in lymph node biopsies of early RA patients and RA-risk individuals, finding increased Tfh cells correlating with B cell numbers and reduced IL-21 production.
bioRxiv · Nov 10, 2021Immunology