Macrophage Activation by a Substituted PyrimidoIndole Increases Anti-Cancer Activity
J. Hardie, J. A. Mas-Rosario, S. Ha, E. M. Rizzo, M. E. Farkas
This paper reports a small molecule TLR agonist, PBI1, that activates macrophages to enhance anti-tumor activity, showing five-fold increased phagocytic efficiency compared to untreated macrophages.
bioRxiv · Mar 18, 2019Pharmacology & Toxicology