S. Ha

An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV

This paper introduces an ACE2 decamer viral trap that neutralizes multiple SARS-CoV-2 variants and related coronaviruses through inhalation, showing durability and effectiveness in preclinical models.

Mature microRNA-binding protein QKI promotes microRNA-mediated gene silencing

The paper identifies QKI as a novel microRNA-binding protein that enhances AGO2/let-7b-mediated gene silencing and suppresses tumor growth.

A TMT-based quantitative proteomics approach toward α-syn PFF associated Lewy Body Dementia (LBD) using α-syn PFF-injected mouse brain tissues

This study uses TMT-based quantitative proteomics to identify proteomic changes in mouse brains injected with α-syn PFF, revealing pathways and proteins associated with LBD.

Proteome-wide microarray-based screening of PAR-binding proteins

The paper identifies 356 PAR-binding proteins using a human protein microarray, revealing new biological roles of PARylation beyond DNA repair.

Iodine staining as a useful probe for distinguishing amyloid fibril polymorphs

The paper demonstrates that iodine staining can distinguish amyloid fibril polymorphs by color differences, linked to specific iodine binding sites and surface structures.

Macrophage Activation by a Substituted PyrimidoIndole Increases Anti-Cancer Activity

This paper reports a small molecule TLR agonist, PBI1, that activates macrophages to enhance anti-tumor activity, showing five-fold increased phagocytic efficiency compared to untreated macrophages.

Bile acid metabolites control Th17 and Treg cell differentiation

This study identifies two bile acid metabolites that regulate Th17 and Treg cell differentiation through distinct mechanisms, affecting immune balance in mice.