Author

J. Jaques

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. Vellenga· 2 shared G. Huls· 2 shared H. Maat· 2 shared J. J. Schuringa· 2 shared A. Brouwers-Vos· 1 shared A. Rodriguez Lopez· 1 shared C. Gravesteijn· 1 shared M. P. de Vries· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

E. Vellenga

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2 papers

Recent·Most cited

USP7 as part of non-canonical PRC1.1 is a druggable target in leukemia

H. Maat, J. Jaques, A. Rodriguez Lopez, S. Hogeling, M. P. de Vries, C. Gravesteijn, A. Brouwers-Vos, G. Huls, E. Vellenga, V. van den Boom, J. J. Schuringa

This study identifies USP7 as a therapeutic target in leukemia, particularly in TP53-mutated AML, by showing its role in non-canonical PRC1.1 complex stability and function.

bioRxiv · Jul 9, 2019Cancer Biology

Using a lentiviral Tet-regulated miR-E shRNA dual color vector to evaluate gene function in human leukemic stem cells in vivo

H. Maat, J. Jaques, E. Vellenga, G. Huls, V. Schuringa, J. J. Schuringa

This study uses a lentiviral vector to inducibly knock down PCGF1 in human leukemia models, showing that timing of gene repression affects treatment efficacy and clonal drift in leukemic stem cells.

bioRxiv · Jul 8, 2019 · PreprintCancer Biology