The heptaprenyl diphosphate synthase (Coq1) is the target of a lipophilic bisphosphonate that protects mice against Toxoplasma gondii infection
M. A. Sleda, Z.-H. Li, R. Behera, B. Baierna, C. Li, J. Junpathong, S. R. Malwal, M. Kawamukai, E. Oldfield, S. N. J. Moreno
This paper identifies Coq1 as a target of a bisphosphonate that inhibits Toxoplasma gondii growth and protects mice from infection.
bioRxiv · Apr 4, 2022Microbiology