Cancer BiologybioRxiv
De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma
D. D. Shi, M. R. Savani, M. M. Levitt…·McBray
This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.
DOI 10.1016/j.ccell.2022.07.011