Direct observation of coordinated assembly of individual native centromeric nucleosomes
A. Popchock, J. Larson, J. Dubrulle, C. L. Asbury, S. Biggins
The paper develops a microscopy assay to study centromeric nucleosome assembly, showing CENP-A can reach centromeres without HJURP but requires it for stable incorporation and AT-rich DNA for efficient deposition.
bioRxiv · Jan 20, 2023Biophysics