Direct Imaging and Identification of Proteoforms up to 70 kDa from Human Tissue
P. Su, J. P. McGee, K. R. Durbin, M. A. R. Hollas, M. Yang, E. K. Neumann, J. L. Allen, B. S. Drown, F. A. Butun, J. B. Greer, B. P. Early, R. T. Fellers, J. M. Spraggins, J. Laskin, J. M. Camarillo, , N. L. Kelleher
This paper introduces PiMS, a method that detects proteoforms up to 70 kDa in human tissue with high spatial resolution, identifying key metabolic enzymes in kidney tissue.
bioRxiv · Dec 7, 2021 · PreprintBiochemistry