M. Yang

The ability of enzymes to preserve reactive conformations with well-positioned residues during enzyme-catalyzed reactions can be an important factor for efficient catalysis: a case study of CARNMT1

This study uses computational simulations to show that preserving reactive conformations with well-positioned residues is critical for catalytic efficiency in CARNMT1, as demonstrated by comparing wild-type and mutant enzymes.

Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

This study shows that acute CDK12 loss in prostate cancer causes HR deficiency via polyadenylation, but chronic loss leads to adaptation, making PARP inhibitors ineffective and suggesting CDK13 targeting as a new therapeutic approach.

Identification of P-type ATPase as a bacterial transporter for host-derived small RNA

This study identifies a bacterial P-type ATPase transporter, PtaT, that specifically binds and mediates the uptake of host-derived tsRNAs in Fusobacterium nucleatum.

Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma

This study shows that the cell of origin in lung adenocarcinoma affects the immunosuppressive state of the tumor microenvironment, with AT1-derived tumors showing an anti-tumor immune profile and AT2-derived tumors showing immunosuppressive features.

Changes in urinary proteome in healthy individuals taking multi-vitamin/mineral supplements

This study shows that taking multi-vitamin/mineral supplements for 2 or 4 weeks changes the urinary proteome, with erythropoietin receptor levels increasing significantly in some individuals.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

The RAE1-STOP1 Module Reduces Sensitivity to Exogenous ABA Treatment by Regulating ABI5 in Arabidopsis

The paper identifies the RAE1-STOP1 module as a negative feedback loop that reduces ABA sensitivity by preventing ABI5 upregulation in Arabidopsis.

MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migration

This study identifies MARK2 as a regulator of Golgi reorientation during cell migration by phosphorylating CAMSAP2 at serine 835, affecting its interaction with USO1.

New isolates refine the ecophysiology of the Roseobacter CHAB-I-5 lineage

The paper isolates two new CHAB-I-5 strains, analyzes their genomes, and proposes a new genus and species, highlighting ecological and physiological differences.

Molecular basis of the biogenesis of a protein organelle for ethanolamine utilization

This study identifies the molecular mechanisms of Eut BMC assembly in Salmonella, revealing a 'Shell-first' pathway and the role of EutQ in cargo encapsulation and BMC formation.

Utilizing transcriptomics and metabolomics reveal drought tolerance mechanism in Nicotiana tabacum

This study combines transcriptomics and metabolomics to identify key genes and metabolites involved in drought tolerance mechanisms in Nicotiana tabacum under varying drought conditions.

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

Gene editing of CD3 epsilon gene to redirect regulatory T cells for adoptive T cell transfer

This paper develops a non-viral CRISPR-Cas12a method to redirect Tregs with CARs by integrating an antigen-binding domain into the CD3 epsilon gene, showing improved antigen-specific function and graft protection in a mouse model.

Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

Protocatechuic acid induces endogenous oxidative stress in CR-hvKP by regulating the EMP-PPP pathway

This study shows that protocatechuic acid (PCA) enhances antibiotic efficacy against carbapenem-resistant hypervirulent Klebsiella pneumoniae by inducing oxidative stress through regulation of the EMP-PPP pathway.

Changes of urine proteome after intragastric administration of polysaccharide iron complex in rats

This study compares urine proteomes of rats before and after polysaccharide-iron complex administration, identifying iron-related proteins and pathways.

Changes of urinary proteome in rats after intragastric administration of zinc gluconate

This study compares the urinary proteome of rats before and after zinc gluconate administration, identifying zinc-related differential proteins and their biological functions.

Changes of urinary proteome in rats after intragastric administration of calcium gluconate

The paper examines changes in the urinary proteome of rats after calcium gluconate administration, identifying calcium-related proteins and their pathway associations.

Antimicrobial resistance, virulence genes profiles and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae strains from captive giant pandas (Ailuropoda melanoleuca)

This study analyzed antibiotic resistance, virulence genes, and molecular epidemiology of CRKP strains from giant pandas, revealing diverse genetic profiles and high genetic diversity.

Urinary protein changes during the short-term growth and development of rats

This study shows that the urine proteome can detect short-term growth and development changes in rats, with 195 differentially expressed proteins identified between Day 0 and Day 6.

Transcranial Photobiomodulation on the Left Prefrontal Cortex Enhances Mandarin Chinese L1 and L2 Complex Sentence Processing Performances

This study shows that transcranial photobiomodulation over the left prefrontal cortex improves sentence processing in Mandarin Chinese L1 and L2 speakers without affecting working memory.

Spectrally Resolved Localization Microscopy with Ultrahigh-Throughput

This paper develops an ultrahigh-throughput SMLM methodology using a color glass filter to achieve sub-10 nm localization and sub-5 nm spectral precision for multicolor imaging.

Rapid and label-free exosome analysis by surface-enhanced Raman spectroscopy using silver nanoparticle substrate based on selective laser ablation and melting of silver nanowire

This paper presents a rapid, label-free method for detecting breast cancer-derived exosomes using SERS with a silver nanoparticle substrate fabricated via laser ablation and melting.

hURAT1 Transgenic Mouse Model for Evaluating Targeted Urate-Lowering Agents

This paper develops a human URAT1 transgenic mouse model to evaluate urate-lowering agents and study URAT1-related pathogenesis in gout.

Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation

The paper identifies distinct hippocampal ensembles that influence dietary choice by encoding nutrient-specific memory and motivation.

Deciphering Cell-types and Gene Signatures Associated with Disease Activity in Rheumatoid Arthritis using Single Cell RNA-sequencing

This study uses single-cell RNA sequencing of PBMCs from RA patients and controls to identify disease-associated cell subsets and gene signatures linked to RA disease activity.

Changes in the urinary proteome of rats after short-term intake of magnesium threonate

This study examines changes in the urinary proteome of rats after short-term magnesium threonate intake, identifying differential proteins linked to magnesium's biological functions.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

Plant-based production of diverse human milk oligosaccharides

This study produces diverse human milk oligosaccharides (HMOs) in transgenic plants, demonstrating their potential for cost-effective and sustainable large-scale production compared to microbial methods.

Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.