Decreased calmodulin recruitment triggers PMCA4 dysfunction and pancreatic injury in cystic fibrosis
J. Maleth, T. Madacsy, A. Varga, N. Papp, B. Deak, B. Tel, P. Pallagi, V. Szabo, J. Fanczal, Z. Rakonczay, Z. Razga, M. Hohwieler, A. Kleger, M. Gray, P. Hegyi
This study shows that reduced CFTR expression in pancreatic ductal cells decreases calmodulin recruitment, leading to PMCA4 dysfunction, mitochondrial damage, and apoptosis, suggesting a potential therapeutic target for cystic fibrosis.
bioRxiv · Sep 10, 2020Cell Biology