ImmunologybioRxiv
Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency
P. A. Flynn, M. D. Long, Y. Kosaka…·E. F. Lind
This study shows FLT3-ITD mutations in AML retain in dendritic cells, altering their phenotype and increasing Th17 T cell frequency.
DOI 10.3389/fimmu.2024.1297338