A. Agarwal

Infrared thermography for plant stress detection in vertical farms: Investigating spatiotemporal variations and exploring solutions via machine learning

This study uses infrared thermography and machine learning to detect plant stress in vertical farms, finding that binary models trained on medial stress levels provide reliable probabilistic stress estimates despite spatiotemporal variations.

Assessing nutritional pigment content and plant health status of green and red leafy vegetables by image analysis: Catching the 'red herring' of plant digital color processing

This study develops digital color analysis models to accurately assess pigment content and plant health in green and red leafy vegetables, showing that certain color features correlate strongly with chlorophyll and anthocyanin levels.

Commensal or pathogen: computational vectorizing microbial genomes for de novo risk assessment and virulence feature discovery in Klebsiella pneumoniae

This paper predicts virulence in Klebsiella pneumoniae using expanded gene function discoveries and machine learning, achieving higher accuracy than traditional methods.

Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency

This study shows FLT3-ITD mutations in AML retain in dendritic cells, altering their phenotype and increasing Th17 T cell frequency.

VAMP2 regulates phase separation of alpha-synuclein

This study shows that VAMP2 regulates alpha-synuclein phase separation through electrostatic interactions and lipid membrane binding, influencing its condensation and vesicle formation.

Inhibition of miR-214 expression by small molecules alleviates head and neck cancer metastasis by targeting ALCAM/TFAP2 signaling.

This study shows that inhibiting miR-214 with EGCG reduces head and neck cancer metastasis by targeting ALCAM/TFAP2 signaling.

Differentially deregulated microRNAs contribute to ultraviolet radiation-induced photocarcinogenesis through immunomodulation: An-analysis of microRNAs expression profiling.

This study identifies differentially expressed miRNAs in UVB-induced skin cancer and shows their role in immunomodulation and photocarcinogenesis.

The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cells.

This study shows IL1β promotes myeloid expansion and self-renewal in TET2-deficient hematopoietic stem/progenitor cells, leading to a premalignant phenotype that can be suppressed by IL1R1 inhibition.

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

This study shows that NAD(H) homeostasis in glycolytic myeloid cells is critical for host protection against tuberculosis, with nicotinamide reducing Mtb lung burden.

Development and evaluation of statistical and Artificial Intelligence approaches with microbial shotgun metagenomics data as an untargeted screening tool for use in food production

This study evaluates AI and statistical methods on microbial shotgun metagenomics data to detect anomalies in fluid milk, showing explainable AI can classify anomalous samples and identify microbial drivers.

PIF4/HEMERA-mediated daytime thermosensory growth requires the Mediator subunit MED14

The Mediator subunit MED14 promotes thermomorphogenesis by interacting with PIF4 and HEMERA to induce the expression of growth-promoting genes at elevated temperatures.

Structure of the rabies virus glycoprotein trimer bound to a pre-fusion specific neutralizing antibody

The paper reports the cryo-EM structure of pre-fusion rabies virus glycoprotein bound to the neutralizing antibody RVA122, revealing its trimeric interface and stabilization mechanism.

Spatiotemporal Modulations in Heterotypic Condensates of Prion and α-Synuclein Control Phase Transitions and Amyloid Conversion

This study investigates how prion protein and α-synuclein form dynamic condensates that influence phase transitions and amyloid conversion through electrostatic interactions and RNA effects.

Smartphone-assisted real-time estimation of chlorophyll and carotenoid contents in spinach following the inversion of red and green color features

The paper develops a smartphone-based method to estimate chlorophyll and carotenoid content in spinach using color feature inversion and linear models.

Fine-tuning the transcriptional regulatory model of adaptation response to phosphate stress in maize (Zea mays L.)

This study identifies Pi-responsive genes in maize and proposes an updated transcriptional regulatory model for Pi starvation response.

High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy

This paper develops a method for high-resolution deep brain imaging in mice using adaptive optics three-photon microscopy and demonstrates its ability to image deep cortical structures and astrocyte calcium transients.

An Intrinsically Disordered Pathological Variant of the Prion Protein Y145Stop Transforms into Self-Templating Amyloids via Liquid-Liquid Phase Separation

This study shows that the Y145Stop variant of the prion protein undergoes liquid-liquid phase separation and transitions into amyloid-like aggregates, highlighting a potential role for intrinsically disordered regions in neurodegenerative diseases.

A cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma

This study develops a cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma, finding that dual inhibition of proteasome and CRM1 pathways induces synergistic cytotoxicity.

Differential in vitro activity of individual drugs and bedaquiline-rifabutin combinations against actively multiplying and nutrient-starved Mycobacterium abscessus

The paper evaluates the in vitro activity of drugs and drug combinations against different growth states of M. abscessus, finding that bedaquiline-rifabutin combinations show potent bactericidal effects.

Integrated genomic view of SARS-CoV-2 in India

The paper analyzes SARS-CoV-2 genomic data from India to trace introduction and local transmission, identifying multiple clades and highlighting the need for molecular surveillance.

Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes

This study identifies p38/MAPK pathway activation as a convergent mechanism driving survival, immune evasion, and metastasis in hormone-resistant prostate cancer.

Integrative and Conjugative Elements (ICE) and Associated Cargo Genes within and across Hundreds of Bacterial Genera

The paper analyzes ICE and associated cargo genes across 200,000 bacterial genomes, finding ICE genomes are common and linked to AMR gene spread and phenotypic resistance.

Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells

The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.

CD146+CD107a+ Mesenchymal Stem/Stromal Cells with Signature Attributes Correlate to Therapeutic Potency as \"First Responders\" to Injury and Inflammation

This study identifies CD146+CD107a+ BM-MSC as a subpopulation with enhanced secretory capacity and therapeutic potency in response to inflammation.

Restoring ancestral microbiome aids beetle adaptation to new diets

The paper shows that restoring ancestral microbiomes improves beetle fitness in novel environments through rapid adaptation.