Aging and interferon gamma response drive the phenotype of neutrophils in the inflamed joint
R. Grieshaber-Bouyer, T. Exner, N. S. Hackert, F. A. Radtke, S. A. Jelinsky, O. Halyabar, A. Wactor, E. Karimizadeh, J. Schettini, A. H. Jonsson, D. A. Rao, L. A. Henderson, C. Mueller-Tidow, H.-M. Lorenz, G. Wabnitz, , P. A. Nigrovic
This study identifies transcriptional and phenotypic changes in synovial fluid neutrophils from arthritis patients, highlighting IFNγ response and aging as key drivers.
bioRxiv · Nov 16, 2021 · PreprintImmunology