SIRT6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes
M. E. Copp, J. Shine, H. L. Brown, K. R. Nimmala, S. Chubinskaya, J. A. Collins, R. Loeser, B. O. Diekman
This study shows that SIRT6 activation improves DNA repair efficiency in aging chondrocytes, reducing DNA damage in both human and mouse models.
bioRxiv · Feb 27, 2023 · PreprintCell Biology