APOBEC3A deaminase catalyzes site-specific editing of transfer RNAs
Karolina Hoffa-Sobiech, J. Sikora, Milosz Ruszkowski, Marta Starczak, Daniel Gackowski, Adam G. Blaszczak, Aleksandra Mierzwa, Magdalena Rakoczy, Małgorzata Marcinkowska, Ireneusz Stolarek, Paulina Jackowiak, Marek Figlerowicz, Lucyna Budzko
This study shows APOBEC3A deaminates tRNAs in vitro and identifies editing sites in tumor tissues, suggesting a role in mistranslation and cancer.
bioRxiv · Jun 10, 2025 · PreprintMolecular Biology