Marek Figlerowicz

Machine learning-guided design of artificial microRNAs for targeted gene silencing

The paper introduces miRarchitect, a machine learning platform for designing artificial microRNAs, showing it produces functional amiRNAs more effectively than existing tools.

APOBEC3A deaminase catalyzes site-specific editing of transfer RNAs

This study shows APOBEC3A deaminates tRNAs in vitro and identifies editing sites in tumor tissues, suggesting a role in mistranslation and cancer.

Short 2'-O-methyl/LNA oligomers as highly-selective inhibitors of miRNA production in vitro and in vivo

This paper develops 2'-OMe/LNA oligonucleotides to selectively inhibit specific miRNA precursors, demonstrating in vitro and in vivo target selectivity for miRNA family members.

Copy number variations shape the structural diversity of Arabidopsis metabolic gene clusters and are associated with the climatic gradient

The paper analyzes copy number variations in Arabidopsis thaliana metabolic gene clusters and links them to climatic adaptation.

Human PUM1 and PUM2 exhibit regulation of divergent mRNA targets in male germ cells

The paper identifies distinct mRNA targets and protein cofactors regulated by PUM1 and PUM2 in human male germ cells, revealing functional divergence in their RNA regulatory roles.