Pretreatment of aged mice with retinoic acid restores alveolar regeneration via upregulation of reciprocal PDGFRA signaling
J. Gokey, J. Snowball, J. Green, M. Waltamath, J. J. Spinney, K. E. Black, L. P. Hariri, Y. Xu, A.-K. T. Perl
This study shows that pretreatment with retinoic acid in aged mice enhances alveolar regeneration by increasing PDGFA signaling, which supports fibroblast activation and epithelial cell differentiation.
bioRxiv · May 6, 2020 · PreprintCell Biology