Bro1 stimulates Vps4 activity to promote Intralumenal Vesicle Formation during Multivesicular Body biogenesis
C.-c. Tseng, S. Dean, B. A. Davies, I. F. Azmi, N. Pashkova, J. A. Payne, J. Staffenhagen, M. West, R. C. Piper, G. Odorizzi, D. Katzmann
This study shows that the Bro1 V domain stimulates Vps4 activity to promote ESCRT-III-driven intralumenal vesicle formation during MVB biogenesis, coordinating cargo sorting with membrane remodeling.
bioRxiv · Jul 27, 2020Cell Biology