Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations
H. N. Thirmanne, F. Wu, D. H. Janssens, J. Swanger, H. Feldman, R. Amezquita, R. Gottardo, P. J. Paddison, S. Henikoff, B. E. Clurman
This study examines the transcriptional effects of Fbw7 mutations in colorectal cancer cells and identifies context-specific regulatory changes and co-regulated genes like CIITA.
bioRxiv · Oct 19, 2021Cancer Biology