F. Wu

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.

Structure of the II2-III2-IV2 mitochondrial supercomplex from the parasite Perkinsus marinus

This study determines the structure of a unique II2-III2-IV2 mitochondrial supercomplex from Perkinsus marinus using cryo-EM, revealing novel subunit arrangements and functional features.

A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

This paper introduces a 3D in vitro assay to study immune cell infiltration and cytotoxicity in solid tumors, showing it captures key steps of immune cell interaction with the tumor microenvironment.

Nociceptive neurons interact directly with gastric cancer cells via a CGRP/Ramp1 axis to promote tumor progression

The paper identifies a CGRP/Ramp1 axis-mediated interaction between nociceptive neurons and gastric cancer cells that promotes tumor progression.

Cognate Antigen Engagement Induces HIV-1 Expression In CD4+ T Cells From People On Long-Term ART

The paper shows that cognate antigen engagement in CD4+ T cells on long-term ART increases HIV-1 transcription through T cell activation, suggesting a role in viral rebound.

Ketone body 3-hydroxybutyrate alleviates CCl4-induced liver fibrosis in mice through regulation of mitochondrial fission and reduction of oxidative stress

This study shows that 3-hydroxybutyrate reduces liver fibrosis in mice by improving mitochondrial function and reducing oxidative stress.

Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer's disease in mice

This study uses single-cell RNA sequencing to identify immune changes in the colon of Alzheimer's disease mice, finding reduced antibody-secreting cells and altered immune trafficking.

RNA-guided RNA silencing by an Asgard archaeal Argonaute

The paper identifies an Asgard archaeal Argonaute, HrAgo1, that performs RNA-guided RNA silencing, bridging the gap between prokaryotic and eukaryotic Argonaute mechanisms.

The absence of yeast Pex23 and Pex29 results in a mitochondrial fusion defect

This study shows that absence of Pex23 and Pex29 in yeast causes mitochondrial fusion defects, independent of membrane contact sites.

pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.

MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants

This study identifies MaUGT79 as a gene regulating scopolin biosynthesis, which enhances drought tolerance in plants through ROS scavenging and transcriptional activation by MaMYB4.

A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation.

This study identifies verteporfin as a potent CCL5/CCR5 axis antagonist that suppresses TNBC tumor growth and metastasis through CCR5-YAP1 regulation.

Last in first out: SIV proviruses seeded later in infection are harbored in short-lived CD4+ T cells

The paper models SIV provirus divergence in CD4+ T cells, finding that short-lived cells harbor more diverged virus, while long-lived cells contain less diverged virus, explaining contradictory prior results on reservoir timing.

Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold

This study investigates the evolution of viperin genes across prokaryotes and eukaryotes, revealing their conservation, diversification mechanisms, and immune functions.

B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters

The paper identifies B cells as drivers of T cell immunosenescence and aging, showing that targeting B cells with CD20 antibodies can reverse age-related T cell dysfunction.

Progressive plasticity during colorectal cancer metastasis

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

LrhA promotes CRISPR-Cas immunity by enhancing primed adaptation in Escherichia coli

This study identifies LrhA as a regulator that enhances CRISPR-Cas immunity in E. coli by promoting adaptation through increased spacer acquisition.

APOBEC3 activity promotes the survival and evolution of drug-tolerant persister cells during acquired resistance to EGFR inhibitors in lung cancer

This study shows APOBEC3 activity supports drug-tolerant persister cells in EGFR inhibitor-resistant lung cancer by promoting transdifferentiation and mutation acquisition.

Lymphoid tissues contribute to viral clonotypes present in plasma at early post-ATI in SIV-infected rhesus macaques

This study identifies secondary lymphoid tissues as a source of SIV clonotypes detected in plasma early after antiretroviral therapy interruption.

Tomato CYP94C1 terminates jasmonate signaling during fruit ripening by inactivating bioactive jasmonoyl-L-isoleucine

This study identifies CYP94C1 as a key enzyme in tomato that terminates jasmonate signaling during ripening by converting bioactive JA-Ile to an inactive form, thereby reducing susceptibility to necrotrophic pathogens.

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

Shin in the eye: Au-CS@FNDs as contact lens additives for blocking UV irradiation, bacterial keratitis, and corneal neovascularizationtherapies

This paper develops Au-CS@FNDs contact lens additives to block UV, prevent bacterial keratitis, and inhibit corneal neovascularization.

COMT inhibitor tolcapone represses the migration and invasion of trophoblast and results in preeclampsia-like phenotypes in mice

This study shows that tolcapone causes embryo lethality and preeclampsia-like phenotypes in mice by inhibiting trophoblast migration and invasion.

High Resolution Salmonella Subtyping by the MLSTnext Method

The paper introduces a high-resolution Salmonella subtyping method using MLSTnext-NGS, which efficiently identifies serovars and resolves mixed strains in food samples.

Acetylation-dependent coupling between G6PD activity and apoptotic signaling

This study shows acetylation of G6PD regulates its activity and links to apoptotic signaling through structural and functional analyses.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

A Deep Learning Approach for Histology-Based Nuclei Segmentation and Tumor Microenvironment Characterization

This study introduces HD-Yolo, a deep learning method for faster and more accurate nuclei segmentation and tumor microenvironment quantification in whole-slide images.

Physiological adaptation of sulfate reducing bacteria in syntrophic partnership with anaerobic methanotrophic archaea

This study examines the metabolic adaptations of sulfate-reducing bacteria in syntrophic partnerships with methanotrophic archaea, revealing unique evolutionary changes in protein pathways.

Flow-induced mechanical coupling between perinuclear actin cap and nucleus governs spatiotemporal regulation of YAP transport

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

Manipulating Oxalate Decarboxylase Provides the Basis of Antilithic Therapy by Acting on the Gut Microbiota

The paper identifies Zn2+ as a therapeutic agent for calcium oxalate kidney stones by enhancing oxalate-degrading bacteria and their enzymes in the gut microbiota.