PathologybioRxivPreprint
Robust W1282X-CFTR rescue by a small molecule GSPT1 degrader
R. E. Lee, C. A. Lewis, L. He…·S. H. Randell
The paper develops Bmi-1/hTERT cell lines to model CFTR variants and shows that CC-90009 partially rescues W1282X-CFTR function while affecting sodium channel activity.
DOI 10.1101/2021.09.28.462149