S. H. Randell

This study shows that viral airway injury enhances cell engraftment in an in vitro CF model by creating conditions that favor non-CF cell integration and functional CFTR recovery.

This study identifies a unique epithelial cell population in human distal airways and shows its reduction in COPD, linked to IFN-gamma signaling.

This study shows visible blue light inactivates SARS-CoV-2 variants and inhibits Delta replication in human airway models, with high efficacy and tolerance.

The paper develops Bmi-1/hTERT cell lines to model CFTR variants and shows that CC-90009 partially rescues W1282X-CFTR function while affecting sodium channel activity.

This study identifies hyperconcentrated mucus as a unifying mechanism for submucosal gland and superficial airway dysfunction in cystic fibrosis.

The paper uses single-cell transcriptomics to analyze proximal airway epithelium in CF and healthy donors, identifying molecular changes linked to CF pathogenesis.

This study corrects multiple CFTR mutations in human airway stem cells using CRISPR/Cas9 and AAV vectors, achieving functional restoration in differentiated epithelial cells.

This study shows DNAJB12 and Hsp70 facilitate conformation-specific degradation of N1303K-CFTR intermediates via ERQC-autophagy, distinct from ERAD.

This study shows the SARS-CoV-2 D614G variant replicates more efficiently and transmits faster in hamsters than the wildtype virus.

The paper uses single-cell RNA sequencing to analyze basal cell diversity in normal and IPF lung, finding increased secretory primed basal cells in IPF and roles for NOTCH2 and NOTCH3 in their regulation.

This study shows that proteolytic cleavage, not receptor binding, is the main barrier for two MERS-like bat coronaviruses to infect human cells, and that trypsin treatment can overcome this barrier.