Natural Killer Cell Dysfunction In Human Bladder Cancer Is Caused By Tissue-Specific Suppression of SLAMF6 Signaling
A. M. Farkas, D. Youssef, M. A. Tran, S. Balan, J. H. Newman, F. Audenet, H. Anastos, L. G. Velazquez, A. Peros, A. Ananthanarayanan, J. Daza, E. Gonzalez-Gugel, K. Sadanala, J. Theorell, M. D. Galsky, , N. Bhardwaj
This study identifies SLAMF6 signaling suppression in bladder cancer tumor microenvironment as a cause of NK cell dysfunction, showing restoration of function under normoxic conditions.
bioRxiv · Apr 30, 2024 · PreprintImmunology