A. Horowitz

Natural Killer Cell Dysfunction In Human Bladder Cancer Is Caused By Tissue-Specific Suppression of SLAMF6 Signaling

This study identifies SLAMF6 signaling suppression in bladder cancer tumor microenvironment as a cause of NK cell dysfunction, showing restoration of function under normoxic conditions.

Single cell view of tumor microenvironment gradients in pleural mesothelioma

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping

The paper creates a single-cell reference map of NK cells and identifies tumor-associated states predictive of patient outcomes in melanoma and osteosarcoma.

Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry & high-resolution microscopy

This study maps human natural killer cell development in pediatric tonsil using imaging mass cytometry and high-resolution microscopy, revealing stage-specific localization and interactions.

Understanding the heterogeneity of alloreactive natural killer cell function inkidney transplantation

This study identifies NK cell subpopulations and their functional responses in kidney transplant patients, linking pre-transplant NK cell characteristics to long-term graft function.

IL-15 synergizes with CD40 agonist antibodies to induce durable immunity against bladder cancer

This study shows that combining IL-15 with CD40 agonist antibodies improves anti-tumor immunity in bladder cancer by enhancing T cell responses and memory.

Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

Cryo-EM Structures of CTP Synthase Filaments Reveal Mechanism of pH-Sensitive Assembly During Budding Yeast Starvation

The paper uses cryo-EM to study CTP synthase filament assembly in yeast, revealing pH-sensitive mechanisms and their role in starvation response.

Inference of Diagnostic Markers and Therapeutic Targets from CSF proteomics for the Treatment of Hydrocephalus

This paper reviews CSF proteomics data to explore biomarkers and therapeutic targets for hydrocephalus but finds current data insufficient for testing these hypotheses.

Validation of a Miniaturized Permeability Assay Compatible with CRISPR-Mediated Genome-Wide Screen

The paper validates a miniaturized permeability assay compatible with CRISPR-mediated genome-wide screens for thrombin-disruptive genes in endothelial cell junctions.

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals

Anti-α4β7 therapy reduces lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals with mild inflammatory bowel disease.