Pharmacology & ToxicologybioRxiv
Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity
T. Yotsumoto, N. Morozumi, R. Nakamura…·K. Kangawa
This study assesses the safety of ASB20123, a C-type natriuretic peptide derivative, showing bone- and cartilage-specific toxicity linked to growth acceleration and identifying epiphyseal plate thickness and BMD as biomarkers.
DOI 10.1371/journal.pone.0218229