Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease
J. Sanchez-Ceinos, R. Guzman-Ruiz, O. A. Rangel-Zuniga, J. Lopez-Alcala, E. Moreno-Cano, M. del Rio-Moreno, J. L. Romero-Cabrera, P. Perez-Martinez, E. Maymo-Masip, J. Vendrell, S. Fernandez-Veledo, J. M. Fernandez-Real, J. Laurencikiene, M. Ryden, A. Membrives, , M. M. Malagon
This study identifies impaired mRNA splicing and ERAD as markers of dysfunctional preadipocytes in obesity-related insulin resistance and type 2 diabetes, showing that restoring PRFP8/PRP8 levels can rescue adipogenesis.
bioRxiv · Jan 15, 2021Cell Biology