Cell BiologybioRxiv
Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease
J. Sanchez-Ceinos, R. Guzman-Ruiz, O. A. Rangel-Zuniga…·M. M. Malagon
This study identifies impaired mRNA splicing and ERAD as markers of dysfunctional preadipocytes in obesity-related insulin resistance and type 2 diabetes, showing that restoring PRFP8/PRP8 levels can rescue adipogenesis.
DOI 10.7554/elife.65996