Inhibition of Topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats
M. Amoiridis, K. Meaburn, J. Verigos, W. H. Gittens, T. Ye, M. J. Neale, E. Soutoglou
This study shows that inhibiting Top2 catalytic activity destabilizes heterochromatin and repetitive DNA, leading to DNA breaks and requiring Ercc1-XPF for resolution.
bioRxiv · Aug 1, 2023 · PreprintCell Biology