T. Ye

Riluzole reverses blood-testis barrier loss to rescue chemotherapy induced male infertility by binding to TRPC

This study shows riluzole restores blood-testis barrier function and rescues chemotherapy-induced male infertility in mice by targeting TRPC5.

Novel synthetic ecteinascidins exhibit potent anti-melanoma activity by suppressing super-enhancer-driven oncogenic transcription

This study shows novel synthetic ecteinascidins effectively treat melanoma by inhibiting super-enhancer-driven oncogenic transcription, even in resistant models.

Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in QIV vaccinated mice.

This study evaluates how lipid nanoparticle (LNP) composition and adjuvant combinations affect immune responses and protection in mice vaccinated against influenza.

Inhibiting the GPI Transamidase Subunit GPAA1 Abolishes CD24 Surface Localization and Enhances Macrophage-Mediated Phagocytosis of Ovarian Cancer Cells

This study identifies GPAA1 as a regulator of CD24 surface expression and shows that inhibiting GPAA1 enhances macrophage-mediated phagocytosis of ovarian cancer cells.

The impact of multiband and in-plane acceleration on white matter microstructure analysis

This study evaluates how multiband and in-plane acceleration affect white matter microstructure analysis in older adults with varying cognitive status, finding both benefits and drawbacks in reliability and group differences.

Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib to amikacin resistance

This paper quantifies the relationship between AAC(6')-Ib enzyme concentration and amikacin resistance in E. coli, showing a linear increase until a plateau due to protein aggregation.

Inhibition of Topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats

This study shows that inhibiting Top2 catalytic activity destabilizes heterochromatin and repetitive DNA, leading to DNA breaks and requiring Ercc1-XPF for resolution.

High red/far-red ratio promotes root colonization of Serratia plymuthica A21-4 in tomato by root exudates-stimulated chemotaxis and biofilm formation

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

This paper designs short, target-binding linear peptides using a contrastive learning framework, demonstrating effective binding and degradation of conformationally diverse proteins.

Mechanism of DNA origami folding elucidated by mesoscopic simulations

This paper develops a mesoscopic simulation model to study DNA origami folding, revealing hierarchical processes and kinetic differences between small and large structures.

KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation

The paper identifies KCNN4 as a mediator linking PIEZO mechanotransduction to NLRP3 inflammasome activation, showing its role in CAPS-related auto-inflammation.

Parasitism and locomotory capacity calibrate the mitogenomic evolutionary rates in Bilateria

The paper examines mitogenomic evolutionary rates in Bilateria, finding that parasitism and reduced locomotory capacity are associated with elevated rates, explaining a significant portion of variance in branch lengths.

Measuring chondrocyte viability of articular cartilage based on label-free two-photon microscopy and deep learning image analysis

This paper develops a deep learning method to assess chondrocyte viability using label-free two-photon microscopy images from rat and porcine cartilage, achieving 95% accuracy.

Super-enhancer driven expression of BAHCC1 promotes melanomacell proliferation and genome stability

The paper identifies BAHCC1 as a super-enhancer-driven gene in melanoma that promotes proliferation and genome stability, showing its potential as a therapeutic target.

A deep learning network for parallel self-denoising and segmentation in visible light optical coherence tomography of human retina

This paper introduces a deep learning framework for simultaneous self-denoising and segmentation of VIS-OCT retinal images, showing improved segmentation performance with reduced annotation requirements.

Distinct mechanisms underlie H2O2 sensing in C. elegans head and tail

The paper shows that C. elegans head and tail neurons use distinct mechanisms to sense H2O2, involving different receptors but shared peroxiredoxin PRDX-2.

Drivers of interlineage variability in mitogenomic evolutionary rates in flatworms (Platyhelminthes) are multifactorial

This study identifies multiple factors influencing mitogenomic evolutionary rates in flatworms, with parasitism having the greatest impact despite its monophyletic origin.

High-dimensional and spatial analysis reveals immune landscape dependent progression in cutaneous squamous cell carcinoma

This study compares immune landscapes of non-progressing and progressing cutaneous squamous cell carcinomas to identify immune features associated with metastasis.

Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks

The paper identifies super-enhancer networks regulating bladder cancer subtypes through transcription factors, showing their role in cell identity and inflammatory response suppression.

Which waters hydrate best? A study using brine-shrimp cysts (Artemia franciscana)

This study evaluates the hydration effectiveness of various waters using brine-shrimp cysts, finding that some bottled waters and mineral water hydrate more effectively than tap water.

Spectral Signatures of L-DOPA-Induced Dyskinesia Depend on L-DOPA Dose and are Suppressed by Ketamine

This study investigates how L-DOPA dose affects neural oscillations in LID and shows ketamine suppresses some of these signatures in specific brain regions.

DNA Nanostructures Coordinate Gene Silencing in Mature Plants

This study evaluates DNA nanostructures for delivering siRNAs to plant cells and silencing genes in Nicotiana benthamiana, showing that nanostructure properties affect delivery and silencing efficiency.