Quantifying the Limits of Immunotherapies in Mice and Men
L. V. Brown, E. A. Gaffney, A. Ager, J. Wagg, M. C. Coles
The paper quantifies the difference in CART-cell delivery rates between humans and mice, finding human delivery rates are much lower, suggesting higher doses may be needed for efficacy in solid tumours.
bioRxiv · Mar 9, 2020 · PreprintCancer Biology